USA Environmental Protection Agency (EPA) 
Proposed rule - EPA is proposing significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for chemical substances that were the subject of premanufacture notices (PMNs).
The chemical substances received "not likely to present an unreasonable risk" determinations pursuant to TSCA. The SNURs require persons who intend to manufacture (defined by statute to include import) or process any of these chemical substances for an activity that is proposed as a significant new use by this rule to notify EPA at least 90 days before commencing that activity. The required notification initiates EPA's evaluation of the use, under the conditions of use for that chemical substance, within the applicable review period.
Persons may not commence manufacture or processing for the significant new use until EPA has conducted a review of the notice, made an appropriate determination on the notice, and has taken such actions as are required by that determination.
86 Federal Register (FR) 64115, 17 November 2021; Title 40 Code of Federal Regulations (CFR) Part 721: https://www.govinfo.gov/content/pkg/FR-2021-11-17/pdf/2021-24785.pdf
This proposed rule is identified by Docket Number EPA-HQ-OPPT-2021-0227. The Docket Folder is available on Regulations.gov at https://www.regulations.gov/docket/EPA-HQ-OPPT-2021-0227/document